Lnc2Cancer, is a manually curated database that provides comprehensive experimentally supported associations between lncRNA and human cancer. The current version of Lnc2Cancer documents 4,989 entries of associations between 1,614 human lncRNAs and 165 human cancer subtypes through review of more than 6,500 published papers. Especially, Lnc2Cancer also provide experimentally supported circulating, drug resistant, prognostic lncRNAs in cancers. Moreover, lncRNAs regulated by microRNA (miRNA), Transcription factor (TF), variant and methylation are also shown.