dbPTM is an integrated resource for protein post-translational modifications (PTMs). Due to the importance of protein post-translational modifications (PTMs) in regulating biological processes, the dbPTM was developed as a comprehensive database by integrating experimentally verified PTMs from several databases and annotating the potential PTMs for all UniProtKB protein entries. The dbPTM has been maintained for over ten years with an attempt to provide comprehensively functional and structural analyses for post-translational modifications (PTMs). In this update, dbPTM not only integrate more experimentally validated PTMs from available databases and manual curation of literature, but also provide disease association based on non-synonymous single nucleotide polymorphisms (nsSNPs