KERIS: The kaleidoscope of gene responses to inflammation among species. A cornerstone of modern biomedical research is the use of mouse models to explore basic disease mechanisms, evaluate new therapeutic approaches, and make decisions to carry new drug candidates forward into clinical trials. However, few of these human trials have shown success. We reported previously that, although acute inflammatory stresses from different etiologies result in highly similar genomic responses in humans, the response of murine ortholog genes poorly correlate with their human counterparts in inflammatory diseases.