This database will enable the reliable identification of an individual IRG or IRG signatures from high throughput data sets (i.e. microarray, proteomic data etc.). It will also assist in identifying regulatory elements, chromosomal location and tissue expression of IRGs in human and mouse. This upgraded version, Interferome v2.0 has quantitative data, more detailed annotation and search capabilities and can be queried for one gene or thousands as in a gene list from a microarray experiment.