Post translational modification (PTM) is an important biochemical process, which occurs after the mRNA is translated into the protein sequence in ribosomes. PTM process the protein by adding different biochemical group (such as phosphorylation (Moorhead et al., 2009), methylation (Chen et al., 2006)), by adding different small protein molecule (such as ubiquitination (Gao et al., 2013), sumoylation (Ren et al., 2009)), and by splicing protein sequence at specific sites (such as caspase cascade (Earnshaw et al., 1999)). PTM is involved in nearly all aspect of biological processes by regulation of protein function. Abnormal PTM status has been reported to be associated with a variety of diseases, including cancers and neurologic diseases (Cohen et al., 2001, Aletta et al., 2008, Sakamoto et al., 2002, McIlwain et al., 2013).