The 10th International Peptide Symposium, in conjunction with the 55th Japanese Peptide Symposium was held at ROHM Theatre Kyoto and Miyako Messe in Kyoto on December 3 to 7, 2018 under the auspices of the Liaison Committee of International Peptide Societies and hosted by the Japanese Peptide Society. The symposium had a total of 517 presentations covering a wide spectrum of topics in peptide science.