The 2004 Nobel Prize in Chemistry was awarded for the discovery of ubiquitin and ubiquitin proteasome system that is a highly-specific, ATP-dependent pathway responsible for targeting specific proteins for degradation. Ubiquitin is a small protein comprising 76 amino acids in eucaryote from plants and fungi to mammals. It makes a large variety of functions because it can be conjugated to target proteins and lead to their destruction (Hershko 1983; Hershko et al., 1975).