The Kahn Dynamic Proteomics project aims at monitoring the position and amounts of endogenous proteins in individual living human cells. This is based on the Library of Annotated Reporter Cell-clones (LARC). Each cell-line clone contains an endogenous protein fused to yellow fluorescent protein (YFP), expressed from its endogenous chromosomal location with its natural regulation. Labeling with YFP was done by exon-tagging (also known as CD-tagging), where YFP, flanked by splice signals, was delivered into the genome using a retrovirus. YFP is then spliced into the protein as a new exon. Protein identity was established by sequencing the cDNA. The cell line used is the H1299 non-small lung cell carcinoma line which stably expressed the viral receptor. This is a robust cell-line with a nicely spread cell morphology that is highly photogenic for microscopy purposes. Several lines of evidence indicate that over 2/3 of the tagged proteins retain their proper functionality and localization.