RBPTD is a database for the systematic investigation of RBP functions and abnormal causes of cancer-related RBPs. The database recognises 1991 cancer-related RBPs including 454 significantly differentially expressed RBPs and 1970 RBPs with significant prognostic value among 28 types of cancer. To explore their functions, target sites of 26 RBPs were identified in this study using CLIP-Seq data. Besides, we found 26?039?691 significantly related RBP-gene regulatory pairs for the remaining RBPs by calculating their Pearson correlation coefficients. Finally, we found 45 CNV-related dysregulated RBPs.