Long noncoding RNAs (lncRNAs) play an important role in modulating gene expression or participating in some essential epigenetic regulation processes, including chromatin modification or DNA methylation. DNA methylation is a fundamental feature of epigenomes that can affect the expression of protein coding or non coding transcripts. Here, we constructed Lnc2Meth, aimed to provide a comprehensive resource and web tool for clarifying the regulatory relationships between human lncRNAs and associated DNA methylation in diverse diseases.