ytochrome P450 is the collective name for a super family of heme-containing monooxygenases that are involved in the production and/or modification of diverse compounds. P450 enzymes not only participate in the production of metabolites important for organism's internal need but also play critical roles in the adaptation in diverse environments by modifying harmful environmental chemicals. Fungi inhabit diverse ecological niches, and P450 enzymes have been shown to contribute to fungal exploration of different niche