Small open reading frames (sORFs) can be defined as open reading frames smaller than or equal to 300 nucleotides (100 amino acids). These “sORFs”, while inherent to all genomes, are historically ignored in gene annotation studies, stating that these lack any coding potential. Exclusion of these sORFs has emerged as a side effect during the development of different (gene prediction) tools in the field of bioinformatics/genomics/proteomics trying to reduce noise, imposed by technological limitations However, recent scientific breakthroughs discovered coding potential of several sORFs with clinical significance, indicating their importance.