Phase separation, or liquid-liquid phase separation (LLPS), is a ubiquitous and important mechanism for the formation of membraneless condensates in cells. LLPS is driven by multivalent macromolecular interactions, whereas resulting condensates have been regarded as an emerging paradigm of cellular organization (Banani et al., 2017; Boeynaems et al., 2018; Shin et al., 2017). Living cells contain various types of membraneless condensates enriched with proteins and RNA molecules. These condensates, including stress granule (Molliex et al., 2015), P-body (Parker et al., 2007), P granule (Brangwynne et al., 2009), spindle apparatus (Jiang et al., 2015) and nucleolus (Hult et al., 2017), play critical roles in regulating a variety of biological processes such as stress response (Riback et al., 2017), RNA metabolism (Taylor et al., 2016), DNA damage response (Patel et al., 2015) and signal transduction (Franzmann et al., 2018).