OrCGDB (http://www.tumor-gene.org/Oral/oral.html) oral cancer gene database has information for only 15 genes without a search engine and interaction network. Our first database with 242 genes was made in 2007 and is available at (http://www.actrec.gov.in/oralcancer/GeneHome.htm). The present database, version II, has been updated to include 374 genes. It has been developed as a user friendly site that would provide the scientist, information and external links from one place.